Scientists have discovered a biological marker that may help to identify which depressed patients will respond to an experimental, rapid-acting antidepressant. The brain signal, detectable by noninvasive imaging, also holds clues to the agent's underlying mechanism, which are vital for drug development, say National Institutes of Health researchers.
How the most critical innovations will affect the industry future with the efforts to reduce the costs of manufacturing a biologic, according to the 10th Annual Report and Survey of Biopharmaceutical Manufacturers.
Implementing an optimized feed medium may be the most effective alternative for modifications to the growth medium in an existing process.
This application note describes the cultivation of Sf-9 suspension cells in the wave-mixed single-use Finesse SmartRocker bioreactor with a maximum working volume of 5 L. Using serum-free, it was possible to produce up to 6.2∙106 cells∙mL-1. The rSEAP expression was induced by the baculovirus expression vector system. Maximum rSEAP activity of up to 58.5 U∙mL-1 was achieved. The results are in the typical range observed in previous cultivations using wave-mixed bioreactor types. By Nadezda Perepelitsa, Stephan C. Kaiser and Dieter Eibl
The aim with this white paper is to discuss the advantages of using Capto Core 700 in virus purification compared to size exclusion chromatography (SEC), a technique commonly used in several vaccine processes.
As with any other type of electrochemical sensor, polarographic dissolved oxygen sensors are not completely trouble-free. As the sensor ages, it may begin to drift or produce more noise in its reading.
One way to lower the suspension viscosity of a drug is through the use of highly-concentrated crystalline suspensions, or protein crystals.
A large variety of chemicals can be efficiently produced by microbial fermentation. They are used in a multitude of applications; for example, as biofuels, building blocks for polymers, food supplements, and ingredients for cosmetics. To be profitable, fermentation processes have to deliver the desired end product at a high yield and a high titer.
America's biopharmaceutical companies are using biological processes to develop 907 medicines and vaccines targeting more than 100 diseases, according to a new report released today by the Pharmaceutical Research and Manufacturers of America (PhRMA).
Research peptides are used around the world for a number of reason but most notably to test the effects of growth hormone related hormones and growth hormone related peptides and their effects.
Generex Biotechnology Corporation (www.generex.com) (OTCBB: GNBT) today provided an overview on the early breast cancer competitive status of the lead cancer immunotherapy product, AE37, under development at its wholly-owned subsidiary, Antigen Express, Inc. (www.antigenexpress.com).
DSM Pharmaceutical Products, the custom manufacturing and technology business of Royal DSM (NYSE, Euronext: DSM KON), announced today that it has signed a non-exclusive license agreement with Amgen Inc. for access to DSM's proprietary XD® high cell density process patents.
BioInvent International AB recently announced that Svein Mathisen has resigned from his positions as chief executive officer of the Company and as member of the Board of Directors.
Glen Allen, VA /PRNewswire/ - Star Scientific, Inc. (NASDAQ: STSI) announced today the preliminary results of the Company's ASAP (Anatabloc Supplementation Autoimmune Prevention) Human Thyroid Study that analyzes the impact of anatabine dietary supplementation on thyroid health.
Gradalis, Inc. today announced that is has closed a $24 million Series B round of financing. Gradalis will use the funding to advance its autologous vaccine platform, FANG™, through late-stage clinical trials and expand manufacturing capabilities to accommodate commercial launch of FANG.
ArmaGen Technologies, Inc., a leader in the delivery of biotherapeutics targeting the central nervous system (CNS), today announced James Callaway , Ph.D. as Chief Executive Office and member of the Board of Directors.